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An in vivo study has shown that daily injection of high-dose ascorbate (4 g/kg) in a leukemic mouse model, promoted DNA demethylation and the expression of genes critical for myeloid cell differentiation, and subsequently recapitulated the TET2 restoration phenotypes (105)

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PGPR also induce plant synthesis of metal-chelating compounds (e.g., glutathione, phytochelatins) and enhance the antioxidant system by mitigating oxidative damage and improving plant health and survival in contaminated soils 62

In activating this enzyme, estrogens upregulate the production of serotonin